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Proton therapy planning

Make your proton therapy planning robust to change

Proton therapy is a highly precise treatment method, which also makes it sensitive to change. We understand this and designed our software and treatment planning system RayStation to account for every eventuality.

Over 100 ion therapy clinics have chosen RayStation® worldwide. What has contributed to this success? Listen to senior product manager Martin Janson discusses his insights from a demo station at ASTRO.


Market leading in particle therapy

Many particle centers worldwide are using RayStation for their proton planning. Probably because RaySearch has been, and continues to be pioneers in cutting edge proton planning techniques. Highlights in RayStation®* 11B include:

  • Presentation of Linear Energy Transfer (LET) distributions
  • Monte Carlo Dose engine now on GPU, cutting the dose computation to under five seconds for most cases
  • Robust optimization and evaluation
  • Machine learning autoplanning with robustness
  • 4D-optimization
  • PBS optimization with apertures
  • Multi-criteria optimization with robustness
  • Fully integrated adaptive planning
  • Automatic creation of backup photon plans
  • Simulated organ motion
  • Ocular planning

We support proton therapy systems from IBA (Proteus® Plus, Proteus®ONE), Varian** (ProBeam®, ProBeam360®), Hitachi (ProBeat), Mevion (HYPERSCAN), Sumitomo and ProNova (SC360). The system offers the full range of treatment options, including pencil beam scanning, double scattering, single scattering, uniform scanning, line scanning and wobbling.

* Subject to regulatory clearance in some markets

** The marks VARIAN and ProBeam are trademarks of Varian Medical Systems, Inc. There is no association, sponsorship and/or endorsement between RaySearch Laboratories AB (publ) and its subsidiaries or related entities with Varian Medical Systems.

The precision of proton therapy makes it a unique treatment method. A basic fact of proton therapy is that high precision also means sensitivity to change. We understand this, and that is why we have designed RayStation to account for every eventuality.

Ever wondered how the 4D robust optimization or the proton Monte Carlo dose engine in RayStation® really works?

Struggled to find reliable references for publishing proton planning results with RayStation? Look no further!
The latest Medical Dosimetry publication, "Treatment planning of scanned proton beams in RayStation", provides a comprehensive description of both basic and advanced proton planning tools in RayStation. Delve into detailed explanations of their underlying algorithms, many of which were previously unavailable to the public. Enjoy unlocking the secrets of RayStation's cutting-edge capabilities!

Access the article HERE


WATCH "Proton update to include LET Optimization"

By Martin Janson, Proton product manager, RaySearch Laboratories

RayStation provides leading tools for designing and optimizing actively scanned pencil beams. Optimization strategies include our pioneering scenario based robust optimization, robust Multi Criteria Optimization, and robust 4D optimization. Accurate dose computation in optimization and final dose is achieved using our lightning fast GPU based Monte Carlo dose engine. RayStation also support PBS planning using patient specific apertures or MLC collimation. The robustness of the optimized plans can be assessed using the dedicated Plan Robustness Evaluation module.

  • GPU Monte Carlo dose engine for optimization and final dose.
  • Optimization of pencil beam scanning and line scanning using multi-field optimization and single field uniform dose techniques.
  • Robust optimization over multiple 4D-CT images, scenario-based optimization regarding uncertainties in range (density) and position (isocenter shifts, target shifts, etc.)
  • Presentation of Linear Energy Transfer (LET) distributions
  • Full control of energy layer spacing and spot pattern
  • Layer repainting
  • Bragg peak visualization
PBS-specific features:
  • Step-and-shoot spot scanning
  • Optimization including lower and upper limits of spot MU delivery
  • Spot visualization with beam’s-eye-view and patient 2D/3D views
  • Manual editing of spot pattern
  • Spot weight filtering
  • Quasi-discrete PBS
  • Spot order sorting through scan path length optimization

Line scanning specific features:
  • Line segment visualization
  • Line segment filtering in optimization with beam’s-eye-view and patient 2D/3D views



RayStation features an extremely fast GPU based Monte Carlo dose engine for proton pencil beam scanning (PBS) plans, which can be used for final dose computation and optimization.

The RayStation Monte Carlo (MC) dose engine for proton PBS planning was introduced in 2016 and was rapidly commissioned for clinical use at many proton centers. Factors driving this success include high speed, the accuracy of computed doses and the fact that MC computed dose can be used for both optimization and final dose.

A vital success factor is that the dose calculation was fast enough for everyday clinical work; previously, MC dose calculation had been considered too slow for routine treatment planning. But while the speed was impressive for an MC algorithm, computation times could still be substantial for large targets. To overcome this, RaySearch accelerated the dose engine by enabling GPU-based computation.

Performance testings show that RayStation 10B can compute clinical MC dose in five seconds or less, even for large targets such as in craniospinal cases. This achievement sets a new standard in computation speed for proton planning without compromising on accuracy.



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Simulated organ motion

The ability to simulate organ motion in RayStation strengthens the functionality of robust planning and plan evaluation even further. With the ability to generate simulated images for organ motion, the full effect of the changing anatomy can be evaluated without the need of acquiring multiple patient CT scans.

Sets of deformed images are generated based on motion expectation for user-selected ROI. The organ motion will affect the overall patient anatomy in cooperation with specified fixed areas. The generated group of motion image sets can be used for both evaluation and as input when planning robustly against intra-fractional or inter-fractional organ motion.

The RayStation® treatment planning system is specifically designed to make adaptive therapy faster and easier in clinical practice. It includes modules for dose tracking and adaptive re-planning.

We are also developing, in collaboration with IBA, an online adaptive workflow solution* where daily cone beam images are taken and matched to the planning CT for a particular patient. Based on the daily images, an updated treatment plan can be automatically suggested to the care team at the time of a treatment session. A plan adaptation that takes the patient’s current situation into account can thus be made before treatment delivery starts. This workflow benefits patients by allowing for more accurate treatments and faster plan adaptation.

*Subject to regulatory clearance in some markets.

Because RayStation is a complete treatment planning system that supports many different modalities, planning of proton treatments in conjunction with photons is possible. The fallback planning module also enables proton plans to be converted into photon plans, ensuring there is no interruption in treatment.

Provision Center for Proton Therapy

See how Provision Center for Proton Therapy achieve great results in Proton PBS with RayStation.


Case study at Texas Center for Proton Therapy

The implementation of treatment planning with 4D-robust optimization and Monte Carlo dose calculation in RayStation, combined with automated volumetric-repainting beam delivery developed at Texas Center for Proton Therapy, allows us to treat lung patients and other moving targets using PBS in a safe and efficient manner. In fact, approximately 15 percent of our current patients are now treated using these techniques.” Dr. Andrew K. Lee, Medical Director of Texas Center for Proton Therapy.